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Name :
Human CD26/DPP4/DPPIV/ADCP2 Protein, ECD (Extracellular Domain), Fc-fusion, Biotinylated, Recombinant

Description :
CD26, also known as DPPIV/DPP4 (dipeptidyl peptidase-4) and ADCP2 (adenosine deaminase complexing protein 2), is a single pass type II transmembrane protein consisting of a short cytoplasmic tail, a transmembrane domain, and a long extracellular domain (ECD). The ECD of CD26 is a serine exopeptidase belonging to the S9B family that cleaves Xaa-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides, and peptide hormones such as glucagon. CD26 plays an important role in many biological and pathological processes. CD2 acts as a T cell-activating molecule and serves as a cofactor for entry of HIV in CD4+ cells. CD26 binds adenosine deaminase, the deficiency of which causes severe combined immunodeficiency disease in humans. CD26 exists as a homodimer on the cell surface and the soluble form is also detectable in human serum and other body fluids. The levels of soluble CD26 may have clinical significance in patients with cancer, liver and kidney diseases, and depression. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). This causes an increase in glucose-dependent stimulation, resulting in a lowering of blood glucose levels. Therefore DPP4 inhibitors represent a new pharmacological class of drugs for treating Type 2 diabetes.

Gene Symbol :

NCBI Gene ID :
1803

Uniprot Entry :
P27487

Construct Details :
The recombinant human CD26-Fc fusion is expressed as a 965 amino acid protein consisting of Asn29 – Pro766 region of CD26 and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.

Source :
Human cells stably expressing human CD26-Fc and growing in chemical-defined media with no animal components or antibiotics

Amino Acid Sequence: :
10 20 30 40 50 60 NKGTDDATAD SRKTYTLTDY LKNTYRLKLY SLRWISDHEY LYKQENNILV FNAEYGNSSV 70 80 90 100 110 120 FLENSTFDEF GHSINDYSIS PDGQFILLEY NYVKQWRHSY TASYDIYDLN KRQLITEERI 130 140 150 160 170 180 PNNTQWVTWS PVGHKLAYVW NNDIYVKIEP NLPSYRITWT GKEDIIYNGI TDWVYEEEVF 190 200 210 220 230 240 SAYSALWWSP NGTFLAYAQF NDTEVPLIEY SFYSDESLQY PKTVRVPYPK AGAVNPTVKF 250 260 270 280 290 300 FVVNTDSLSS VTNATSIQIT APASMLIGDH YLCDVTWATQ ERISLQWLRR IQNYSVMDIC 310 320 330 340 350 360 DYDESSGRWN CLVARQHIEM STTGWVGRFR PSEPHFTLDG NSFYKIISNE EGYRHICYFQ 370 380 390 400 410 420 IDKKDCTFIT KGTWEVIGIE ALTSDYLYYI SNEYKGMPGG RNLYKIQLSD YTKVTCLSCE 430 440 450 460 470 480 LNPERCQYYS VSFSKEAKYY QLRCSGPGLP LYTLHSSVND KGLRVLEDNS ALDKMLQNVQ 490 500 510 520 530 540 MPSKKLDFII LNETKFWYQM ILPPHFDKSK KYPLLLDVYA GPCSQKADTV FRLNWATYLA 550 560 570 580 590 600 STENIIVASF DGRGSGYQGD KIMHAINRRL GTFEVEDQIE AARQFSKMGF VDNKRIAIWG 610 620 630 640 650 660 WSYGGYVTSM VLGSGSGVFK CGIAVAPVSR WEYYDSVYTE RYMGLPTPED NLDHYRNSTV 670 680 690 700 710 720 MSRAENFKQV EYLLIHGTAD DNVHFQQSAQ ISKALVDVGV DFQAMWYTDE DHGIASSTAH 730 740 750 760 770 780 QHIYTHMSHF IKQCFSLPDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV 790 800 810 820 830 840 VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK 850 860 870 880 890 900 VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE 910 920 930 940 950 960 SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGK

M.W. :
Calculated molecular mass (kDa): 111; Estimated by SDS-PAGE under reducing condition (kDa): ~120

Calculated PI :
5.84

Calculated Extinction Coefficients :
(M-1 cm-1, at 280nm): 229975

Endotoxin Level :
>92% judged by SDS-PAGE under reducing condition (see the gel image above)

Formulation :
Supplied at 0.25 mg/ml in sterile PBSpH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule) using the standard procedure.

Endotoxin Level :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method

Biological Activity :

Molecule Class :
1-Pass Type II Transmembrane

Gene Synonym :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method

Gene Family :
CD26; DPP4; ADABP; ADCP2; DPPIV; TP103

Research Area :
Immunology

Pathway/Disease :
T Cell Co-stimulation

Species :
Human

CD Antigen :
CD26

References :

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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