Product Name :
VU0483605
Description:
VU0483605 is a selective positive allosteric modulator (PAM) of mGluR1 . The metabotropic glutamate receptors (mGluRs), members of G-protein-coupled receptors, have been involved in a variety of functions in the central and peripheral nervous systems, such as learning, memory, anxiety, and the perception of pain. The mGluRs exist in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, the cerebral cortex, as well as other parts of the brain and in peripheral tissues. Mice deficient in mGluR1 showed severe motor coordination and spatial learning deficient . VU0483605 is a selective positive allosteric modulator (PAM) of mGluR1. VU0483605 displayed EC50 values of 0.39 and 0.36 μM at human and rat mGluR1 receptors, respectively. VU0483605 showed no activity against mGlu4 PAM with the EC50 of >10 μM. VU0483605 potentiated the response to glutamate in cells stably expressing mGlu1 and partially restored the reduction in glutamate-mediated calcium signaling in a mutant cell model of schizophrenia .
CAS:
1623101-11-0
Molecular Weight:
446.{{Atazanavir} web|{Atazanavir} Metabolic Enzyme/Protease|{Atazanavir} Biological Activity|{Atazanavir} Purity|{Atazanavir} manufacturer|{Atazanavir} Autophagy} 67
Formula:
C20H10Cl3N3O3
Chemical Name:
3-chloro-N-[3-chloro-4-(4-chloro-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)phenyl]pyridine-2-carboxamide
Smiles :
O=C1C2C(=CC=CC=2Cl)C(=O)N1C1=CC=C(C=C1Cl)NC(=O)C1N=CC=CC=1Cl
InChiKey:
HJQXPBKPTGWZCF-UHFFFAOYSA-N
InChi :
InChI=1S/C20H10Cl3N3O3/c21-12-4-1-3-11-16(12)20(29)26(19(11)28)15-7-6-10(9-14(15)23)25-18(27)17-13(22)5-2-8-24-17/h1-9H,(H,25,27)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Clindamycin} web|{Clindamycin} Antibiotic|{Clindamycin} Purity & Documentation|{Clindamycin} In Vitro|{Clindamycin} manufacturer|{Clindamycin} Cancer}
Shelf Life:
≥12 months if stored properly.PMID:34337881
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
VU0483605 is a selective positive allosteric modulator (PAM) of mGluR1 . The metabotropic glutamate receptors (mGluRs), members of G-protein-coupled receptors, have been involved in a variety of functions in the central and peripheral nervous systems, such as learning, memory, anxiety, and the perception of pain. The mGluRs exist in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, the cerebral cortex, as well as other parts of the brain and in peripheral tissues. Mice deficient in mGluR1 showed severe motor coordination and spatial learning deficient . VU0483605 is a selective positive allosteric modulator (PAM) of mGluR1. VU0483605 displayed EC50 values of 0.39 and 0.36 μM at human and rat mGluR1 receptors, respectively. VU0483605 showed no activity against mGlu4 PAM with the EC50 of >10 μM. VU0483605 potentiated the response to glutamate in cells stably expressing mGlu1 and partially restored the reduction in glutamate-mediated calcium signaling in a mutant cell model of schizophrenia .|Product information|CAS Number: 1623101-11-0|Molecular Weight: 446.67|Formula: C20H10Cl3N3O3|Chemical Name: 3-chloro-N-[3-chloro-4-(4-chloro-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)phenyl]pyridine-2-carboxamide|Smiles: O=C1C2C(=CC=CC=2Cl)C(=O)N1C1=CC=C(C=C1Cl)NC(=O)C1N=CC=CC=1Cl|InChiKey: HJQXPBKPTGWZCF-UHFFFAOYSA-N|InChi: InChI=1S/C20H10Cl3N3O3/c21-12-4-1-3-11-16(12)20(29)26(19(11)28)15-7-6-10(9-14(15)23)25-18(27)17-13(22)5-2-8-24-17/h1-9H,(H,25,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
