Mouse SEZ6 Protein 3619

Additional Information:
inaccessionQ7TSK2|express systemHEK293|product tagC-His|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundSeizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the -amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface.|molecular weightThe protein has a predicted MW of 98.8 kDa. Due to glycosylation, the protein migrates to 145-150 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Mouse SEZ6 Protein 3619proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceSeizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the -amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface.Protein namesSeizure protein 6 (SEZ-6) (Brain-specific receptor-like protein C) (BSRP-C)Gene namesSez6,Sez6 Kiaa4158Protein familySEZ6 familyMass10090DaFunctionMay play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity.Subellular location[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Note=Localized on dendrites and in the postsynaptic fraction. Does not appear to be enriched at synapses, at least not in the presynaptic axon terminal.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein. Synapse. Cell projection, dendrite. Note=Localized on dendrites and in the synaptic and postsynaptic fraction.; [Isoform 3]: Secreted. Cytoplasm.TissuesBrain-specific. Expressed in extrasynaptic and synaptic subcellular fractions (at protein level). Expression correlates with the most active periods of cortical neurogenesis and neuronal maturation. Expression is restricted to the gray matter with higher levels in the forebrain including the olfactory bulb, anterior olfactory nuclei, olfactory tubercle, striatum, hippocampal CA1 pyramidal cell layer and cerebral cortex. Expression is up-regulated with the convulsant drug, pentylenetetrazole.Post-translational modificationGlycosylated.Target Relevance information above includes information from UniProt accession: Q7TSK2The UniProt Consortium|