Cynomolgus Syndecan-1 Protein 2508

Additional Information:
accession XP_005576533.2|express systemHEK293|product tagC-His|purity> 90% as determined by Tris-Bis PAGE|backgroundLiver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on the surfaces of hepatocytes and cholangiocytes. Due to liver diseases the amount of syndecan-1 increases in the liver.|molecular weightThe protein has a predicted MW of 24.97 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Cynomolgus Syndecan-1Protein 2508proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceLiver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on the surfaces of hepatocytes and cholangiocytes. Due to liver diseases the amount of syndecan-1 increases in the liver.Protein namesSyndecan-1 (SYND1) (CD antigen CD138)Protein familySyndecan proteoglycan familyMass32462DaFunctionCell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). PubMed:22660413.Subellular locationMembrane ECO:0000255; Single-pass type I membrane protein ECO:0000255. Secreted ECO:0000269. Secreted, extracellular exosome PubMed:22660413. Note=Shedding of the ectodomain produces a soluble form. PubMed:9169435.TissuesDetected in placenta (at protein level) (PubMed:32337544). Detected in fibroblasts (at protein level) (PubMed:36213313). ECO:0000269.StructureInteracts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain). Interacts with MDK (By similarity). ECO:0000250.Post-translational modificationShedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3. PubMed:9169435.Target Relevance information above includes information from UniProt accession: P18827The UniProt Consortium|