**Background** Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that plays a critical role in signal transduction downstream of immunoreceptors, including the B-cell receptor (BCR) and Fc receptors. Dysregulation…
**Background** Proteolysis-targeting chimeras (PROTACs) have emerged as a revolutionary class of bifunctional molecules designed to selectively degrade disease-causing proteins. Unlike traditional inhibitors that only block the active site of a…
**Background** Folate is a critical B-vitamin essential for DNA synthesis, repair, and methylation. A deficiency in folate during early pregnancy is strongly linked to the development of neural tube defects…
**Background** Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders characterized by a deficiency in one of the enzymes required for the synthesis of cortisol in the adrenal…
Early diagnosis of HIV infection remains a critical challenge in global public health, particularly due to the limitations of conventional testing methods in resource-limited settings. The p24-HIV protein serves as…
Droplet interface bilayer (DIB) platforms occupy a unique space at the intersection of synthetic materials and biological systems, offering a versatile framework for constructing functional, life-like architectures. By leveraging the…
Dichlorvos exposure is increasingly linked to chronic hepatorenal injury characterized by progressive fibrosis, a pathological process involving excessive deposition of extracellular matrix proteins that disrupts tissue architecture and function. Although…
The management of severe hyperglycemia in conditions such as diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) requires rapid, potent, and durable suppression of glucagon-mediated hepatic glucose output. While insulin…
The mechanical integrity and microstructural homogeneity of pulp capping materials are paramount to their long-term clinical success. This study investigated the synergistic enhancement of Angelus Mineral Trioxide Aggregate (A-MTA) through…
The electrochemical synthesis of hydrogen peroxide (H₂O₂) via the two-electron oxygen reduction reaction (2e- ORR) in acidic media presents a sustainable and scalable alternative to conventional anthraquinone processes. However, achieving…