“Cot-tpi2 (MAP3K8, Mitogen-activated protein kinase kinase kinase eight) is an enzyme that in individuals is encoded by the MAP3K8 gene. This gene was identified by its oncogenic transforming action in cells. Cot-tpi2 is a member of the serine/threonine protein kinase relatives. Cot-tpi2 can activate each the MAP kinase and JNK kinase pathways. Cot-tpi2 is demonstrated to activate IkappaB kinases, and consequently induce the nuclear output of NF-kappaB. Cot-tpi2 is also located to market the creation of TNF-alpha and IL-2 in the course of T lymphocyte activation. Scientific studies of a comparable gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may well also utilize a downstream in-frame translation begin codon, and hence generate an isoform that contains a shorter N-terminus. The shorter isoform has been revealed to display weaker reworking action.