**Background** Leukemia is a malignant cancer of the blood and bone marrow characterized by the uncontrolled proliferation of abnormal white blood cells. Splicing factor mutations are frequently observed in various…
**Background** The ghrelin receptor, also known as the growth hormone secretagogue receptor (GHSR-1a), plays a critical role in the regulation of energy homeostasis, appetite, and growth hormone secretion. Ghrelin, the…
**Background** P2X receptors are a family of ligand-gated ion channels activated by extracellular adenosine triphosphate (ATP), playing critical roles in various physiological processes, including neurotransmission, inflammation, and vascular tone regulation.…
**Background** The development of sophisticated RNA nanostructures has opened new avenues in the fields of synthetic biology and precision medicine. RNA assemblies, characterized by their ability to organize molecules into…
**Background** Allergic rhinitis and asthma are prevalent inflammatory conditions characterized by the release of histamine, which triggers various physiological responses through the activation of histamine receptors. Among these, the histamine…
**Background** Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that plays a critical role in signal transduction downstream of immunoreceptors, including the B-cell receptor (BCR) and Fc receptors. Dysregulation…
**Background** Proteolysis-targeting chimeras (PROTACs) have emerged as a revolutionary class of bifunctional molecules designed to selectively degrade disease-causing proteins. Unlike traditional inhibitors that only block the active site of a…
**Background** Folate is a critical B-vitamin essential for DNA synthesis, repair, and methylation. A deficiency in folate during early pregnancy is strongly linked to the development of neural tube defects…
**Background** Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders characterized by a deficiency in one of the enzymes required for the synthesis of cortisol in the adrenal…
Early diagnosis of HIV infection remains a critical challenge in global public health, particularly due to the limitations of conventional testing methods in resource-limited settings. The p24-HIV protein serves as…