Name :
Human IL13RA2/CD213a2/IL13BP/IL13R2 Protein, ECD (Extracellular Domain), Fc-fusion, Recombinant
Description :
IL13RA2 (Interleukin-13 receptor subunit alpha-2), also known as CD213a2 and IL13BP (IL13-binding protein), is a single-pass type I transmembrane protein belonging to the type I cytokine receptor family. Like IL13RA1, the extracellular domain (ECD) of IL13RA1 contains 3 fibronectin type III domains, D1, D2, and D3, of which the last two comprise the cytokine receptor homology modules (CRHs). In contrast to IL13RA1, IL13RA2 binds IL-13 with a high affinity but lacks cytoplasmic domain, and does not appear to function as a signal mediator. IL-13RA2 is widely expressed and detected on many types of cancer cells including glioblastoma, AIDS Kaposi’s sarcoma, and head & neck cancer. IL-13 binds two types of receptor: (1) a heterodimer of the IL13 RA1 and the IL4RA, transducing the IL13-dependent proliferative signal; and (2) the IL13RA2, acting as a nonsignaling “decoy” receptor by binding and internalizing IL13. IL13RA2 can also block IL4-induced responses by inhibiting IL4 bound IL13RA1/IL4RA receptor complexes even though it does not bind IL 4 directly. Aside from its decoy function, IL13-IL13RA2 binding directly promotes the development of tissue fibrosis. IL13RA2 may also play an important role in the Th2 polarized immune responses characteristic of a variety of pathologies, including parasitic infections and allergic asthma. IL-13Rα2 exists both on the cell membrane and in soluble form which are generated from distinct transcripts.
Gene Symbol :
NCBI Gene ID :
3598
Uniprot Entry :
Q14627
Construct Details :
The recombinant human IL13RA2-Fc fusion is expressed as a 552 amino acid protein consisting of Asp27 – Thr340 region of IL13RA2 and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.
Source :
Human cells stably expressing human IL13RA2-Fc and growing in chemical-defined media with no animal components or antibiotics
Amino Acid Sequence: :
10 20 30 40 50 60 DTEIKVNPPQ DFEIVDPGYL GYLYLQWQPP LSLDHFKECT VEYELKYRNI GSETWKTIIT 70 80 90 100 110 120 KNLHYKDGFD LNKGIEAKIH TLLPWQCTNG SEVQSSWAET TYWISPQGIP ETKVQDMDCV 130 140 150 160 170 180 YYNWQYLLCS WKPGIGVLLD TNYNLFYWYE GLDHALQCVD YIKADGQNIG CRFPYLEASD 190 200 210 220 230 240 YKDFYICVNG SSENKPIRSS YFTFQLQNIV KPLPPVYLTF TRESSCEIKL KWSIPLGPIP 250 260 270 280 290 300 ARCFDYEIEI REDDTTLVTA TVENETYTLK TTNETRQLCF VVRSKVNIYC SDDGIWSEWS 310 320 330 340 350 360 DKQCWEGEDL SKKTSTTENL YFQGSTGTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR 370 380 390 400 410 420 TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN 430 440 450 460 470 480 GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR EEMTKNQVSL TCLVKGFYPS 490 500 510 520 530 540 DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH 550 YTQKSLSLSP GK
M.W. :
Calculated molecular mass (kDa): 63.4; Estimated by SDS-PAGE under reducing condition (kDa): ~90
Calculated PI :
5.23
Calculated Extinction Coefficients :
(M-1 cm-1, at 280nm): 136805
Endotoxin Level :
>90% judged by SDS-PAGE under reducing condition (see the gel image above, labeled as “DTT: +”)
Formulation :
Supplied at 0.5 mg/ml in sterile PBSpH7.4 (carrier & preservative free).
Endotoxin Level :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Biological Activity :
Binds to its human ligand IL13/IL4 and blocks IL13/IL4-induced signaling activity and proliferation of human erythroleukemic cells.
Molecule Class :
1-Pass Type I Transmembrane
Gene Synonym :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Gene Family :
IL13RA2; CD213a2; IL-13RA2; IL13BP; IL13R2
Research Area :
Immunology
Pathway/Disease :
IL13 & IL4 Signaling Pathways
Species :
Human
CD Antigen :
CD213a2
References :
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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