Name :
Human ACVR1C/ALK7 Protein, ECD (Extracellular Domain), Fc-fusion, Recombinant
Description :
The TGFβ (transforming growth factor β) superfamily proteins are pleiotropic cytokines that regulate a diverse range of cellular processes, including proliferation, differentiation, migration, adhesion and death. The TGFβ superfamily elicits 4 signaling pathways: TGFβ, Bone Morphogenic Protein (BMP), Activin, and Nodal. Each pathway signals through a heteromeric receptor complex composed of at least two type-I and two type-II transmembrane receptors containing cytoplasmic serine/threonine kinase domains. These receptors are distinguished by the presence of a glycine/serine-rich juxta-membrane domain found only in the type I receptors. Either type receptor may initially bind ligand, followed by the recruitment of an alternate-type receptor counterpart to form a signal-activating complex. The type I receptors are also referred to as ALKs (Activin receptor-like kinases). ACVR1C (Activin receptor type-1C), also known as ALK7, ActR-IC, and ACVRLK7, is a type I receptor in the TGFβ receptor (TGFBR) family. ACVR1C acts as a type-I receptor to transduce signals of activin and Nodal. ACVR1C is expressed in pancreas, heart, colon, small intestine, ovary and brain. Upon ligand binding, ACVR1C associates with the type II receptor ACVR2A to form a signaling complex that activates AVCR1C through phosphorylation. The activated ACVR1C in turn initiates downstream events by phosphorylation of its effectors to regulate gene expression and affect cellular phenotype. ACVR1C may play an important role in cell differentiation, growth arrest and apoptosis.
Gene Symbol :
ACVR1C; ALK7; ALK-7; ActRIC; ACTR-IC; ACVRLK7; ACVRIC; ACVR-IC
NCBI Gene ID :
130399
Uniprot Entry :
Q8NER5
Construct Details :
The recombinant human ACVR1C/ALK7-Fc fusion protein is expressed as a 320 amino acid protein consisting of Leu22 – Glu113 region of ACVR1C (UniProt accession #Q8NER5) and a C-terminal Fc fusion from human IgG1, which exists as a dimer under non-reducing condition (see the gel image above, labeled as “DTT: -“)
Source :
Human cells stably expressing human ACVR1C-Fc and growing in chemical-defined media with no animal components or antibiotics
Amino Acid Sequence: :
LSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVF CHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMESTGTHTCPPCPAPE LLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHN AKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYK TTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP GK
M.W. :
Calculated molecular mass (kDa): 35.5; Estimated by SDS-PAGE under reducing condition (kDa): 50-55
Calculated PI :
6.54
Calculated Extinction Coefficients :
(M-1 cm-1, at 280nm): 41910
Endotoxin Level :
>95% judged by SDS-PAGE under reducing condition (see the gel image above, labeled as “DTT: +”)
Formulation :
Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free).
Endotoxin Level :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Biological Activity :
Immobilized ACVR1C binds human Nodal in a functional ELISA. Blocks Nodal-mediated signaling activity.
Molecule Class :
Serine/Threonine Kinase Receptor
Gene Synonym :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Gene Family :
ALK7; ALK-7; ActRIC; ACTR-IC; ACVRLK7; ACVRIC; ACVR-IC
Research Area :
Development
Pathway/Disease :
Activin/Nodal Signaling Pathway
Species :
Human
CD Antigen :
References :
1. Oncogene 8:2879 (1993). 2. Science 264:101 (1994). 3. J. Biol. Chem. 271:30603 (1996). 4. J. Clin. Endocrinol. Metab. 89:5523 (2004). 5. Nature. 482:251 (2012).
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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