Rrelation in between macrophage cholesterol efflux and HDL phospholipid in human sera is stronger than with any other measured lipoprotein parameter, like HDL cholesterol, APOA1 and triglycerides48. CETP expression, on the other hand, appears to effect HDL function with no modulating phospholipid levels suggesting that numerous elements of HDL can influence particle function. LXRs likely regulate various pathways that modulate HDL activity and future research employing detailed lipidomic and proteomic approaches could be made use of to further define the LXR-dependent changes in HDL composition that regulate HDL particle function. These studies that define particle function could open the door to new therapeutic approaches for targeting HDL.NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptSupplementary MaterialRefer to Net version on PubMed Central for supplementary material.AcknowledgmentsThe authors would like to thank Dr. Norbert Leitinger and Dr. Irena Ignatova (U. of Virginia) for comments around the manuscript and Dr.s Yuan Zhang, Steven Kliewer and David Mangelsdorf (UT Southwestern) for offering the LXR liver knockout mice. SOURCES OF FUNDING Function inside the author’s laboratory is supported by Grants to I.G.S. from the NIH (1R01HL096864-01A1) and also the AHA (13GRNT1650022).Nonstandard Abbreviations and AcronymsABCA1 ABCG1 ABCG5 ABCG8 APOA1 CETP CVD FPLC HDL LDL LXR RCT ATB binding cassette transporter A1 ATB binding cassette transporter G1 ATB binding cassette transporter G5 ATB binding cassette transporter G8 apolipoprotein A1 cholesteryl ester transfer protein cardiovascular illness quickly CDK4 Inhibitor Source liquid protein chromatography higher density lipoprotein low density lipoprotein liver X receptor reverse cholesterol transportArterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2015 August 01.Breevoort et al.Page
Bradley et al. BMC Geriatrics 2014, 14:72 biomedcentral/1471-2318/14/RESEARCH ARTICLEOpen AccessPotentially inappropriate prescribing amongst older men and women in the United KingdomMarie C Bradley5, Nicola Motterlini2^, Shivani Padmanabhan4, Caitriona Cahir3, Tim Williams4, Tom Fahey2 and Carmel M HughesAbstractBackground: Potentially inappropriate prescribing (PIP) in older men and women is connected with increases in morbidity, hospitalisation and mortality. The objective of this study was to estimate the prevalence of and things connected with PIP, among those aged 70 years, within the United kingdom, employing a comprehensive set of prescribing indicators and comparing these to estimates obtained from a truncated set of the exact same indicators. Solutions: A retrospective cross-sectional study was carried out in the UK Clinical Practice Research Datalink (CPRD), in 2007. Participants integrated those aged 70 years, in CPRD. Fifty-two PIP indicators in the Screening Tool of Older Persons Potentially Inappropriate Prescriptions (STOPP) criteria had been applied to information on prescribed drugs and clinical IDO1 Inhibitor drug diagnoses. Overall prevalence of PIP and prevalence as outlined by person STOPP criteria had been estimated. The partnership amongst PIP and polypharmacy (4 medicines), comorbidity, age, and gender was examined. A truncated, subset of 28 STOPP criteria that have been utilised in two prior research, were further applied towards the information to facilitate comparison. Benefits: Employing 52 indicators, the all round prevalence of PIP within the study population (n = 1,019,491) was 29 . By far the most typical examples of PIP have been therapeutic duplication (11.9 ), followed by use of aspirin.
