Share this post on:

Name :
Human AMHR2 Protein, ECD (Extracellular Domain), Fc-fusion, Recombinant

Description :
The TGFβ (transforming growth factor β) superfamily proteins are pleiotropic cytokines that regulate a diverse range of cellular processes, including proliferation, differentiation, migration, adhesion and death. The TGFβ superfamily elicits 4 signaling pathways: TGFβ, Bone Morphogenic Protein (BMP), Activin, and Nodal. Each pathway signals through a heteromeric receptor complex composed of at least two type-I and two type-II transmembrane receptors containing cytoplasmic serine/threonine kinase domains. These receptors are distinguished by the presence of a glycine/serine-rich juxta-membrane domain found only in the type I receptors. Either type receptor may initially bind ligand, followed by the recruitment of an alternate-type receptor counterpart to form a signal-activating complex. AMHR2 (Anti-Müllerian hormone type 2 receptor), also known as MRII and MISRII, is a type II receptor that forms a heteromeric complex with various type I TGFBRs to mediate AMH (anti-Müllerian hormone) or MIS (Müllerian inhibiting substance) signaling. AMH/MIS, in addition to testosterone, plays a critical role in male sex differentiation. AMH and testosterone are produced in the testes by different cells and show different effects. Testosterone promotes the development of male genitalia, while the binding of AMH/MIS to AMHR2 prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in the AMHR2 are associated with persistent Müllerian duct syndrome type 2 (PMDS2). AMHR2 may suppress tumorigenesis in testes.

Gene Symbol :

NCBI Gene ID :

Uniprot Entry :

Construct Details :
The recombinant human AMHR2-Fc fusion protein is expressed as a 354 amino acid protein consisting of Pro18 – Ser144 region of AMHR2 (UniProt accession #Q16671) and a C-terminal Fc fusion from human IgG1, which exists as a dimer under non-reducing condition (see the gel image above, labeled as “DTT: -“).

Source :
Human cells stably expressing human AMHR2-Fc and growing in chemical-defined media with no animal components or antibiotics

Amino Acid Sequence: :

M.W. :
Calculated molecular mass (kDa): 39.0; Estimated by SDS-PAGE under reducing condition (kDa): 50-55

Calculated PI :

Calculated Extinction Coefficients :
(M-1 cm-1, at 280nm): 44890

Endotoxin Level :
>95% judged by SDS-PAGE under reducing condition (see the gel image above, labeled as “DTT: +”)

Formulation :
Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free).

Endotoxin Level :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method

Biological Activity :
Recombinant AMHR2 protein binds human AMH/MIS and blocks AMH/MIS-induced signaling activity

Molecule Class :
Serine/Threonine Kinase Receptor

Gene Synonym :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method

Gene Family :

Research Area :

Pathway/Disease :
AMH/MIS Signaling Pathway

Species :

CD Antigen :

References :
1. Development 120:189 (1994). 2. Nat. Genet. 11:382 (1995). 3. Endocrinology 137:160 (1996). 4. Hum. Mol. Genet. 5:1269 (1996). 5. Carcinogenesis. 33:2351(2012).

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites:
Popular product recommendations:
Angiogenin-4 Protein
HGFA/HGF Activator Protein
Popular categories:
SARS-CoV-2 S Protein
Ubiquitin-Specific Protease 2

Share this post on: