Name :
Human ROR2 Protein, ECD (Extracellular Domain), Recombinant
Description :
ROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as NTRKR2 (neurotrophic tyrosine kinase, receptor-related 2), is a single-pass type I transmembrane glycoprotein that belongs to the ROR subfamily of the tyrosine protein kinase family. The ROR subfamily members, ROR1 and ROR2, are tyrosine kinase receptors important in regulating skeletal and neuronal development, cell migration and cell polarity. Each ROR member contains 1 FZ (frizzled) domain, 1 Ig (immunoglobulin)-like C2-type domain, and 1 kringle domain in the extracellular region and 1 protein kinase domain in the cytoplasmic region. ROR2 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. ROR2 may be involved in the early formation of the chondrocytes and required for cartilage and growth plate development. ROR2 exists as a homodimer on the cell surface and may mediate a signaling pathway that promotes osteogenesis and bone formation. Mutations in the ROR2 gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. ROR2 appears to possess dual roles as a tumor suppressor or activator depending on tumor type.
Gene Symbol :
ROR-2; BDB; BDB1; NTRKR2
NCBI Gene ID :
4920
Uniprot Entry :
Q01974
Construct Details :
The recombinant human ROR2 ECD is expressed as a 381 amino acid protein consisting of Glu34 – Gly403 region of ROR2 (Uniprot #Q01974) and a C-terminal His-Tag. It contains 3 potential sites for N-linked glycosylation.
Source :
Human cells stably expressing ROR2 ECD and growing in chemical-defined media with no animal components or antibiotics.
Amino Acid Sequence: :
10 20 30 40 50 60 EVEVLDPNDP LGPLDGQDGP IPTLKGYFLN FLEPVNNITI VQGQTAILHC KVAGNPPPNV 70 80 90 100 110 120 RWLKNDAPVV QEPRRIIIRK TEYGSRLRIQ DLDTTDTGYY QCVATNGMKT ITATGVLFVR 130 140 150 160 170 180 LGPTHSPNHN FQDDYHEDGF CQPYRGIACA RFIGNRTIYV DSLQMQGEIE NRITAAFTMI 190 200 210 220 230 240 GTSTHLSDQC SQFAIPSFCH FVFPLCDARS RTPKPRELCR DECEVLESDL CRQEYTIARS 250 260 270 280 290 300 NPLILMRLQL PKCEALPMPE SPDAANCMRI GIPAERLGRY HQCYNGSGMD YRGTASTTKS 310 320 330 340 350 360 GHQCQPWALQ HPHSHHLSST DFPELGGGHA YCRNPGGQME GPWCFTQNKN VRMELCDVPS 370 380 CSPRDSSKMG STGHHHHHHH H M.W.: Calculated molecular mass (kDa): 42.7; Estimated by SDS-PAGE under reducing condition (kDa): 55-60 Calculated PI: 6.50 Calculated Extinction Coefficients (M-1 cm-1, at 280nm): 35505 Purity: >95% judged by SDS-PAGE under reducing condition (see the gel image above) Formulation: Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier free). Endotoxin Level: Biological Activity: Not Available
M.W. :
Calculated molecular mass (kDa): 42.7; Estimated by SDS-PAGE under reducing condition (kDa): 55-60
Calculated PI :
6.50
Calculated Extinction Coefficients :
Endotoxin Level :
>95% judged by SDS-PAGE under reducing condition (see the gel image above)
Formulation :
Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier free).
Endotoxin Level :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Biological Activity :
Not Available
Molecule Class :
Receptor Tyrosine Kinase (RTK)
Gene Synonym :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Gene Family :
BDB; BDB1; NTRKR2
Research Area :
Cancer
Pathway/Disease :
Wnt Signaling Pathway
Species :
Human
CD Antigen :
References :
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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