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Name :
Human B7-H7 protein (extracellular domain), Fc-fusion, recombinant

Description :
B7-H7 (B7 homolog 7), also known as HHLA2 (human endogenous retrovirus-H long terminal repeat-associating protein 2), is regarded as a new member of the B7 ligand family. B7-H7 contains 1 Ig-like (immunoglobulin-like) C1-type and 2 Ig-like V-type domains while other members are typically composed of 1 Ig-like V-type and 1 Ig-like C1-type domains. Interactions between members of the B7 ligand and CD28/CTLA4 receptor families can generate positive co-stimulation and negative co-inhibition in regulating T cell responses. B7-H7 is expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. In immune cells, B7-H7 is highly expressed in B-cells, dendritic cells, monocytes and macrophages, but not detected in T-cells. B7-H7 was reported to regulate cell-mediated immunity by binding to a putative receptor on T lymphocytes and inhibiting the proliferation of T cells. B7-H7 has also been referred to as B-H5 (B7 homolog 5), which was identified as a specific ligand for CD28H (CD28 homolog) or TMIGD2 (transmembrane and Ig domain-containing protein 2). B7-H5 is constitutively found in macrophages and could be induced on dendritic cells in response to inflammation. The B7-H5/CD28H interaction was shown to selectively co-stimulate human T-cell growth and cytokine production via an AKT-dependent signalling cascade.

Gene Symbol :

NCBI Gene ID :

Uniprot Entry :

Construct Details :
The recombinant human B7-H7-Fc fusion protein is expressed as a 574 amino acid protein consisting of Ile23 – Lys345 region of HHLA2/B7-H7 (UniProt accession #Q9UM44) and a C-terminal Fc fusion from human IgG1, which exists as a dimer under non-reducing condition.

Source :
Human cells stably expressing B7-H7-Fc and growing in chemical-defined media with no animal components or antibiotics

Amino Acid Sequence: :

M.W. :
Calculated molecular mass 65.0 kDa; estimated by SDS-PAGE under reducing condition ~75 kDa probably due to glycosylation

Calculated PI :

Calculated Extinction Coefficients :

Endotoxin Level :
>95% judged by SDS-PAGE under reducing condition (see the gel image above)

Formulation :
Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier free).

Endotoxin Level :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method

Biological Activity :
Inhibits anti-CD3 antibody induced cytokine (e.g., IFN- and IL-2) secretion in human T lymphocytes

Molecule Class :
1-Pass Type I Transmembrane

Gene Synonym :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method

Gene Family :
HHLA2; B7H7; B7-H5; B7H5

Research Area :

Pathway/Disease :
T Cell Costimulation

Species :

CD Antigen :

References :

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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