Name :
Human IL17RA/CD217/IL17R Protein, ECD (Extracellular Domain), Fc-fusion, Recombinant
Description :
IL17 (interleukin 17) is a proinflammatory cytokine secreted by activated T-lymphocytes IL17 induces the maturation of hematopoietic precursors into neutrophils. IL-17Ra (IL17 receptor A), also known as, IL17R and CD217, is a single pass type I transmembrane glycoprotein that acts as a low affinity receptor for IL17A, C and F. IL17RA binds IL17A or IL17F homodimers as part of a heterodimeric complex with IL17RC. IL17RA also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. IL17RA acts as a receptor for IL17C as part of a heterodimeric complex with IL17RE. Activation of IL17RA-mediated signaling pathway leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6. IL17 and its receptor IL17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis (RA). Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5), which is a primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida.
Gene Symbol :
NCBI Gene ID :
23765
Uniprot Entry :
Q96F46
Construct Details :
The recombinant human IL17Ra-Fc fusion is expressed as a 524 amino acid protein consisting of Leu33 – Met318 region of IL17Ra and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.
Source :
Human cells stably expressing human IL17Ra-Fc and growing in chemical-defined media with no animal components or antibiotics
Amino Acid Sequence: :
10 20 30 40 50 60 LRLLDHRALV CSQPGLNCTV KNSTCLDDSW IHPRNLTPSS PKDLQIQLHF AHTQQGDLFP 70 80 90 100 110 120 VAHIEWTLQT DASILYLEGA ELSVLQLNTN ERLCVRFEFL SKLRHHHRRW RFTFSHFVVD 130 140 150 160 170 180 PDQEYEVTVH HLPKPIPDGD PNHQSKNFLV PDCEHARMKV TTPCMSSGSL WDPNITVETL 190 200 210 220 230 240 EAHQLRVSFT LWNESTHYQI LLTSFPHMEN HSCFEHMHHI PAPRPEEFHQ RSNVTLTLRN 250 260 270 280 290 300 LKGCCRHQVQ IQPFFSSCLN DCLRHSATVS CPEMPDTPEP IPDYMPSTTE NLYFQGSTGT 310 320 330 340 350 360 HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE 370 380 390 400 410 420 VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP 430 440 450 460 470 480 REPQVYTLPP SREEMTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS 490 500 510 520 FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGK
M.W. :
Calculated molecular mass (kDa): 60; Estimated by SDS-PAGE under reducing condition (kDa): 90-95
Calculated PI :
6.31
Calculated Extinction Coefficients :
(M-1 cm-1, at 280nm): 71485
Endotoxin Level :
>95% judged by SDS-PAGE under reducing condition (see the gel image above)
Formulation :
Supplied at 0.5 mg/ml in sterile PBSpH7.4 (carrier & preservative free).
Endotoxin Level :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Biological Activity :
Molecule Class :
1-Pass Type I Transmembrane
Gene Synonym :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Gene Family :
IL17RA; CD217; IL17R; CANDF5; CDw217; IL-17RA; hIL-17R
Research Area :
Immunology
Pathway/Disease :
IL17 Signaling Pathways
Species :
Human
CD Antigen :
CD217
References :
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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