Product Name :
Rabbit anti-POLD2 Polyclonal Antibody
Synonym :
Host :
Rabbit
Species Reactivity:
Human, Mouse, Rat
Specificity :
Predicted Reactivity:
Applications :
WB 1:500 – 1:2000
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 120-360 of human POLD2 (NP_006221.2).
Concentration :
Purification :
Affinity purification
Clonality:
Polyclonal Antibody
Storage Temp.:
Store at -20 ℃Avoid freeze / that cycles
Research areas :
Background :
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3′ to 5′ exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5.
UniProt :
P49005
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Host Rabbit |Species Reactivity Human, Mouse, Rat |Applications WB 1:500 – 1:2000 |Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 120-360 of human POLD2 (NP_006221.2). |Positive control HeLa,HL-60,HepG2,BT-474,NCI-H460,Mouse testis |Properties |Purification Affinity purification |Clonality Polyclonal Antibody |Isotype IgG |Storage Temp. Store at -20 ℃Avoid freeze / that cycles |Storage Buffer Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |Target |Background This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3′ to 5′ exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. |Cellular localization Nucleus |UniProt P49005 |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-POLD2 Polyclonal Antibody
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
923950-08-7 Purity & Documentation 3026986-17-1 Purity PMID:29262091 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com
