Name :
Human IL13RA1/CD213a1/CT19/IL13R1 Protein, ECD (Extracellular Domain), Fc-fusion, Recombinant
Description :
IL13RA1 (Interleukin-13 receptor subunit alpha-1), also known as CD213a1 and CT19 (cancer/testis antigen 19), is a subunit of the IL13 receptor complex. The human IL13RA1 is a single-pass type I transmembrane protein belonging to the type I cytokine receptor family. The extracellular domain (ECD) of IL13RA1 contains 3 fibronectin type III domains, D1, D2, and D3, of which the last two comprise the cytokine receptor homology modules (CRHs). IL13RA1 binds IL13 with a low affinity by itself and forms a functional receptor for IL13 together with IL4RA, a subunit shared by IL13 and IL4 receptors. The biological effects of IL13 and IL4 are closely related in part due to a shared receptor system. IL-13 binds two types of receptor: (1) a heterodimer of the IL13 RA1 and the IL4RA, transducing the IL13-dependent proliferative signal; and (2) the IL13RA2, acting as a nonsignaling “decoy” receptor. IL13RA1 also serves as an alternate accessory protein to the common cytokine receptor gamma chain for IL4 signaling, but cannot replace the function of IL2RG in enhancing IL2 binding activity. IL13RA1 has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
Gene Symbol :
NCBI Gene ID :
3597
Uniprot Entry :
P78552
Construct Details :
The recombinant human IL13RA1-Fc fusion is expressed as a 560 amino acid protein consisting of Gly22 – Thr343 region of IL13RA1 and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.
Source :
Human cells stably expressing human IL13RA1-Fc and growing in chemical-defined media with no animal components or antibiotics
Amino Acid Sequence: :
10 20 30 40 50 60 GGGGAAPTET QPPVTNLSVS VENLCTVIWT WNPPEGASSN CSLWYFSHFG DKQDKKIAPE 70 80 90 100 110 120 TRRSIEVPLN ERICLQVGSQ CSTNESEKPS ILVEKCISPP EGDPESAVTE LQCIWHNLSY 130 140 150 160 170 180 MKCSWLPGRN TSPDTNYTLY YWHRSLEKIH QCENIFREGQ YFGCSFDLTK VKDSSFEQHS 190 200 210 220 230 240 VQIMVKDNAG KIKPSFNIVP LTSRVKPDPP HIKNLSFHND DLYVQWENPQ NFISRCLFYE 250 260 270 280 290 300 VEVNNSQTET HNVFYVQEAK CENPEFERNV ENTSCFMVPG VLPDTLNTVR IRVKTNKLCY 310 320 330 340 350 360 EDDKLWSNWS QEMSIGKKRN STSTTENLYF QGSTGTHTCP PCPAPELLGG PSVFLFPPKP 370 380 390 400 410 420 KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT 430 440 450 460 470 480 VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSREE MTKNQVSLTC 490 500 510 520 530 540 LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV 550 560 MHEALHNHYT QKSLSLSPGK
M.W. :
Calculated molecular mass (kDa): 63.6; Estimated by SDS-PAGE under reducing condition (kDa): 90-100
Calculated PI :
5.98
Calculated Extinction Coefficients :
(M-1 cm-1, at 280nm): 102425
Endotoxin Level :
>95% judged by SDS-PAGE under reducing condition (see the gel image above, labeled as “DTT: +”)
Formulation :
Supplied at 0.5 mg/ml in sterile PBSpH7.4 (carrier & preservative free).
Endotoxin Level :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Biological Activity :
Binds to its human ligand IL13/IL4 and blocks IL13/IL4-induced signaling activity and proliferation of human erythroleukemic cells.
Molecule Class :
1-Pass Type I Transmembrane
Gene Synonym :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Gene Family :
IL13RA1; NR4; CT19; CD213A1; IL13R; IL13RA; IL-13Ra; IL13R1
Research Area :
Immunology
Pathway/Disease :
IL13 & IL4 Signaling Pathways
Species :
Human
CD Antigen :
CD213a1
References :
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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