Name :
Human CD362/SDC2/HSPG/syndecan2 Protein, ECD (Extracellular Domain), Fc-fusion, Recombinant
Description :
CD362, also known as SDC2 (syndecan 2), Fibroglycan and HSPG (heparan sulfate proteoglycan core protein), is a transmembrane (type I) heparan sulfate proteoglycan of the syndecan proteoglycan family. The syndecans mediate cell adhesion, signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. CD362 is a 201 amino acid (aa) single pass type I transmembrane protein. CD362 contains an N-terminal signal peptide, a 126-aa extracellular domain (ECD) with 4 potential glycosylation sites, a transmembrane domain (TM), and a short 32-aa cytoplasmic tail. CD362 may act as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. CD362 may also regulates dendritic arbor morphogenesis. Altered syndecan-2 expression has been detected in several different tumor types.
Gene Symbol :
Glu19 – Leu139 region of SDC2 and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.
NCBI Gene ID :
6383
Uniprot Entry :
P34741
Construct Details :
The recombinant human SDC2-Fc is expressed as a 349-amino acid protein consisting of Glu19 – Leu139 region of SDC2 and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.
Source :
Human cells stably expressing human SDC2-Fc and growing in chemical-defined media with no animal components or antibiotics
Amino Acid Sequence: :
10 20 30 40 50 60 ESRAELTSDK DMYLDNSSIE EASGVYPIDD DDYASASGSG ADEDVESPEL TTSRPLPKIL 70 80 90 100 110 120 LTSAAPKVET TTLNIQNKIP AQTKSPEETD KEKVHLSDSE RKMDPAEEDT NVYTEKHSDS 130 140 150 160 170 180 LSTGTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY 190 200 210 220 230 240 VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK 250 260 270 280 290 300 AKGQPREPQV YTLPPSREEM TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL 310 320 330 340 DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
M.W. :
Calculated molecular mass (kDa): 38.8; Estimated by SDS-PAGE under reducing condition (kDa): 50-65
Calculated PI :
5.02
Calculated Extinction Coefficients :
(M-1 cm-1, at 280nm): 41745
Endotoxin Level :
>90% judged by SDS-PAGE under reducing condition (see the gel image above, labeled as “S” and “M” for marker)
Formulation :
Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free).
Endotoxin Level :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Biological Activity :
Molecule Class :
1-Pass Type I Transmembrane
Gene Synonym :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Gene Family :
SDC2; SDC-2; CD362; SYND2; syndecan2; HSPG; HSPG1
Research Area :
Cancer
Pathway/Disease :
Leukocyte Migration
Species :
Human
CD Antigen :
CD362
References :
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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