Name :
Human CD6/TP120/T12 Protein, ECD (Extracellular Domain), Fc-fusion, Recombinant
Description :
CD6, also known as TP120, is a single-pass type I membrane protein of the group B scavenger receptor cysteine-rich (SRCR) superfamily. CD6 contains three SRCR domains in the extracellular region. CD6 is a cell surface glycoprotein expressed primarily on T cells and thus a T-cell differentiation antigen. CD6 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some neuronal cells in the brain. CD6 may function as both a co-stimulatory molecule in T cell activation and as an adhesion receptor. As a cell adhesion molecule, CD6 mediates cell-cell contacts and regulates T cell responses via its interaction with the ligand ALCAM (activated leukocyte cell adhesion molecule) or CD166. CD6 partially associates with the TCR/CD3 complex and colocalizes with it at the center of the mature immunological synapse on T lymphocytes. CD6/ALCAM interactions are thought to play a role in thymocyte development. CD6 may also contribute to signaling cascades triggered by activation of the TCR/CD3 complex and the overall functional avidity of selection. CD6 also functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. CD6 binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. CD6 thus mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS. CD6 may be associated with susceptibility to multiple sclerosis
Gene Symbol :
NCBI Gene ID :
923
Uniprot Entry :
P30203
Construct Details :
The recombinant human CD6-Fc is expressed as a 619-amino acid protein consisting of His18 – Glu398 region of CD6 and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.
Source :
Human cells stably expressing human CD6-Fc and growing in chemical-defined media with no animal components or antibiotics
Amino Acid Sequence: :
10 20 30 40 50 60 HPSPAPPDQL NTSSAESELW EPGERLPVRL TNGSSSCSGT VEVRLEASWE PACGALWDSR 70 80 90 100 110 120 AAEAVCRALG CGGAEAASQL APPTPELPPP PAAGNTSVAA NATLAGAPAL LCSGAEWRLC 130 140 150 160 170 180 EVVEHACRSD GRRARVTCAE NRALRLVDGG GACAGRVEML EHGEWGSVCD DTWDLEDAHV 190 200 210 220 230 240 VCRQLGCGWA VQALPGLHFT PGRGPIHRDQ VNCSGAEAYL WDCPGLPGQH YCGHKEDAGA 250 260 270 280 290 300 VCSEHQSWRL TGGADRCEGQ VEVHFRGVWN TVCDSEWYPS EAKVLCQSLG CGTAVERPKG 310 320 330 340 350 360 LPHSLSGRMY YSCNGEELTL SNCSWRFNNS NLCSQSLAAR VLCSASRSLH NLSTPEVPAS 370 380 390 400 410 420 VQTVTIESSV TVKIENKESR ESTTENLYFQ GSTGTHTCPP CPAPELLGGP SVFLFPPKPK 430 440 450 460 470 480 DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV 490 500 510 520 530 540 LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSREEM TKNQVSLTCL 550 560 570 580 590 600 VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM 610 HEALHNHYTQ KSLSLSPGK
M.W. :
Calculated molecular mass (kDa): 67.3; Estimated by SDS-PAGE under reducing condition (kDa): 90-100.
Calculated PI :
5.62
Calculated Extinction Coefficients :
(M-1 cm-1, at 280nm): 112225
Endotoxin Level :
>95% judged by SDS-PAGE under reducing condition (see the gel image above, labeled as “DTT: +”)
Formulation :
Supplied at 0.5 mg/ml in sterile PBSpH7.4 (carrier & preservative free).
Endotoxin Level :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Biological Activity :
Binds to its ligand ALCAM/CD166 and neutralizes ALCAM/CD166-mediated signaling activity.
Molecule Class :
1-Pass Type I Transmembrane
Gene Synonym :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Gene Family :
CD6; TP120; T12
Research Area :
Immunology
Pathway/Disease :
TCR Signaling
Species :
Human
CD Antigen :
CD6
References :
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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