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Name :
Human TACSTD2/TROP2/EGP1/GP50/M1S1/GA7331 Protein, ECD (Extracellular Domain), Fc-fusion, Biotinylated, Recombinant

Description :
TACSTD2 (tumor-associated calcium signal transducer 2), also known as Trop2, M1S1, EGP1, GA733-1, gp50 and T16, is a single-pass type I transmembrane glycoprotein of the EPCAM family. It was originally defined by the monoclonal antibody GA733. TACSTD2 may be formed by the retroposition of the EPCAM gene. TACSTD2 and EPCAM share ~49% amino acid identity and ~67% similarity. TACSTD2 is highly expressed in a wide variety of epithelial cancers, while little or no expression in adult normal tissue. TACSTD2 is a cell surface receptor that transduces calcium signals and may play a role in tumor growth. TACSTD2 may also have cell adhesive functions. Mutations of the TACSTD2 gene are associated with gelatinous drop-like corneal dystrophy. TACSTD2 is a target for immunotherapy treatment of human carcinomas.

Gene Symbol :

NCBI Gene ID :
4070

Uniprot Entry :
P09758

Construct Details :
The recombinant human TACSTD2-Fc fusion is expressed as a 488 amino acid protein consisting of His27 – Gly276 region of TACSTD2 and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions

Source :
Human cells stably expressing human TACSTD2-Fc and growing in chemical-defined media with no animal components or antibiotics

Amino Acid Sequence: :
10 20 30 40 50 60 HTAAQDNCTC PTNKMTVCSP DGPGGRCQCR ALGSGMAVDC STLTSKCLLL KARMSAPKNA 70 80 90 100 110 120 RTLVRPSEHA LVDNDGLYDP DCDPEGRFKA RQCNQTSVCW CVNSVGVRRT DKGDLSLRCD 130 140 150 160 170 180 ELVRTHHILI DLRHRPTAGA FNHSDLDAEL RRLFRERYRL HPKFVAAVHY EQPTIQIELR 190 200 210 220 230 240 QNTSQKAAGD VDIGDAAYYF ERDIKGESLF QGRGGLDLRV RGEPLQVERT LIYYLDEIPP 250 260 270 280 290 300 KFSMKRLTAG STTENLYFQG STGTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV 310 320 330 340 350 360 TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY 370 380 390 400 410 420 KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSREEMT KNQVSLTCLV KGFYPSDIAV 430 440 450 460 470 480 EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGK

M.W. :
Calculated molecular mass (kDa): 54.7 Estimated by SDS-PAGE under reducing condition (kDa): 60-65.

Calculated PI :
8.05

Calculated Extinction Coefficients :
(M-1 cm-1, at 280nm): 53955

Endotoxin Level :
>90% judged by SDS-PAGE under reducing condition (see the gel image above, labeled as “DTT: +”)

Formulation :
Supplied at 0.5 mg/ml in sterile PBSpH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule) using the standard procedure.

Endotoxin Level :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method

Biological Activity :
Supports the adhesion of U937 human histiocytic lymphoma cells to the plate immobilized with TACSTD2 protein

Molecule Class :
1-Pass Type I Transmembrane

Gene Synonym :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method

Gene Family :
TACSTD2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1

Research Area :
Cancer

Pathway/Disease :
Cell Adhesion

Species :
Human

CD Antigen :

References :

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