Human CD24/CD24A Protein, ECD (Extracellular Domain), Fc-fusion, Biotinylated, Recombinant

Description :
CD24 or CD24A is a mucin-type glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on the surface of B cells, granulocytes, epithelial, neuronal, and muscle cells, and on a range of tumor cells. The precursor of CD24 is cleaved to a short 32 amino acid mature peptide that is anchored to the cell surface by GPI. CD24 modulates B-cell activation responses. CD24 promotes antigen-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. Antibody crosslinking of CD24 enhances the induction of apoptosis in B and T cells, which contributes to negative selection and the induction of immune tolerance. CD24 on antigen presenting cells cooperates with B7 molecules in the costimulation of T cells. CD24 may be a genetic modifier for risk and progression of multiple sclerosis. CD24 serve as a receptor for P-selectin. CD24 is involved in molecular adhesion and metastatic tumor spread by facilitating the interaction with platelet and endothelial cells. CD24 is considered as a tumor marker and high expressions can be detected in epithelial ovarian cancer, breast cancer, non-small cell lung cancer, prostate cancer and pancreatic cancer.