Name :
Human CD105/Endoglin/ENG/END/HHT1 Protein, ECD (Extracellular Domain), Fc-fusion, Biotinylated, Recombinant
Description :
CD105 or Endoglin (ENG) is a single-pass type I transmembrane glycoprotein. It is a homodimer and a major glycoprotein of the vascular endothelium. CD105 is involved in the regulation of angiogenesis and plays a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. CD105 is a also component of the transforming growth factor beta receptor (TGFBR)complex and it binds to the beta1 and beta3 peptides with high affinity. CD105 acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. CD105 is required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3. Mutations in the CD105 gene cause hereditary hemorrhagic telangiectasia (HHT1), also known as Osler-Rendu-Weber syndrome 1 (ORW1), an autosomal dominant multisystemic vascular dysplasia. The CD105 gene is also implicated in preeclampsia and several types of cancer.
Gene Symbol :
NCBI Gene ID :
2022
Uniprot Entry :
P17813
Construct Details :
The recombinant human CD105-Fc fusion is expressed as a 789 amino acid protein consisting of Glu26 – Gly586 region of CD105 and a Fc from human IgG1, which exists as a dimer under non-reducing conditions.
Source :
Human cells stably expressing human CD105-Fc and growing in chemical-defined media with no animal components or antibiotics
Amino Acid Sequence: :
10 20 30 40 50 60 ETVHCDLQPV GPERGEVTYT TSQVSKGCVA QAPNAILEVH VLFLEFPTGP SQLELTLQAS 70 80 90 100 110 120 KQNGTWPREV LLVLSVNSSV FLHLQALGIP LHLAYNSSLV TFQEPPGVNT TELPSFPKTQ 130 140 150 160 170 180 ILEWAAERGP ITSAAELNDP QSILLRLGQA QGSLSFCMLE ASQDMGRTLE WRPRTPALVR 190 200 210 220 230 240 GCHLEGVAGH KEAHILRVLP GHSAGPRTVT VKVELSCAPG DLDAVLILQG PPYVSWLIDA 250 260 270 280 290 300 NHNMQIWTTG EYSFKIFPEK NIRGFKLPDT PQGLLGEARM LNASIVASFV ELPLASIVSL 310 320 330 340 350 360 HASSCGGRLQ TSPAPIQTTP PKDTCSPELL MSLIQTKCAD DAMTLVLKKE LVAHLKCTIT 370 380 390 400 410 420 GLTFWDPSCE AEDRGDKFVL RSAYSSCGMQ VSASMISNEA VVNILSSSSP QRKKVHCLNM 430 440 450 460 470 480 DSLSFQLGLY LSPHFLQASN TIEPGQQSFV QVRVSPSVSE FLLQLDSCHL DLGPEGGTVE 490 500 510 520 530 540 LIQGRAAKGN CVSLLSPSPE GDPRFSFLLH FYTVPIPKTG TLSCTVALRP KTGSQDQEVH 550 560 570 580 590 600 RTVFMRLNII SPDLSGCTSK GVDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE 610 620 630 640 650 660 VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE 670 680 690 700 710 720 YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSREEM TKNQVSLTCL VKGFYPSDIA 730 740 750 760 770 780 VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
M.W. :
Calculated molecular mass (kDa): 86.4; Estimated by SDS-PAGE under reducing condition (kDa): 100-105 and 75-85
Calculated PI :
6.24
Calculated Extinction Coefficients :
(M-1 cm-1, at 280nm): 80215
Endotoxin Level :
>90% judged by SDS-PAGE under reducing condition (see the gel image above)
Formulation :
Supplied at 0.5 mg/ml in sterile PBSpH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule) using the standard procedure.
Endotoxin Level :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Biological Activity :
Molecule Class :
1-Pass Type I Transmembrane
Gene Synonym :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Gene Family :
CD105; Endoglin; ENG; END; HHT1; ORW1
Research Area :
Cancer
Pathway/Disease :
TGFβ Signaling Pathway
Species :
Human
CD Antigen :
CD105
References :
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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