Name :
Human CD93/C1qR1/CDw93/MXRA4 Protein, ECD (Extracellular Domain), Fc-fusion, Biotinylated, Recombinant
Description :
CD93 is a single-pass type I transmembrane protein and a member of the calcium dependent C-type lectin superfamily. CD93 contains 1 C-type lectin domain and 5 EGF-like domains in the extracellular region. CD93 was originally identified as a myeloid cell-specific marker and was thought to be a receptor for C1q. CD93 may be involved in intercellular adhesion and in the clearance of apoptotic cells. CD93 is highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils but not expressed in cells of lymphoid origin. CD93 interacts with HCV core protein. CD93 also binds C1qBP; the association may represent a cell surface C1q receptor. The intracellular cytoplasmic tail of CD93 may interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton.
Gene Symbol :
NCBI Gene ID :
22918
Uniprot Entry :
O9NPY3
Construct Details :
The recombinant human CD93-Fc fusion is expressed as a 785 amino acid protein consisting of Ala24 – Lys580 region of CD93 and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.
Source :
Human cells stably expressing human CD93-Fc and growing in chemical-defined media with no animal components or antibiotics
Amino Acid Sequence: :
10 20 30 40 50 60 ADTEAVVCVG TACYTAHSGK LSAAEAQNHC NQNGGNLATV KSKEEAQHVQ RVLAQLLRRE 70 80 90 100 110 120 AALTARMSKF WIGLQREKGK CLDPSLPLKG FSWVGGGEDT PYSNWHKELR NSCISKRCVS 130 140 150 160 170 180 LLLDLSQPLL PSRLPKWSEG PCGSPGSPGS NIEGFVCKFS FKGMCRPLAL GGPGQVTYTT 190 200 210 220 230 240 PFQTTSSSLE AVPFASAANV ACGEGDKDET QSHYFLCKEK APDVFDWGSS GPLCVSPKYG 250 260 270 280 290 300 CNFNNGGCHQ DCFEGGDGSF LCGCRPGFRL LDDLVTCASR NPCSSSPCRG GATCVLGPHG 310 320 330 340 350 360 KNYTCRCPQG YQLDSSQLDC VDVDECQDSP CAQECVNTPG GFRCECWVGY EPGGPGEGAC 370 380 390 400 410 420 QDVDECALGR SPCAQGCTNT DGSFHCSCEE GYVLAGEDGT QCQDVDECVG PGGPLCDSLC 430 440 450 460 470 480 FNTQGSFHCG CLPGWVLAPN GVSCTMGPVS LGPPSGPPDE EDKGEKEGST VPRAATASPT 490 500 510 520 530 540 RGPEGTPKAT PTTSRPSLSS DAPITSAPLK MLAPSGSPGV WREPSIHHAT AASGPQEPAG 550 560 570 580 590 600 GDSSVATQNN DGTDGQKVDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV 610 620 630 640 650 660 VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK 670 680 690 700 710 720 VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSREEMTKNQ VSLTCLVKGF YPSDIAVEWE 730 740 750 760 770 780 SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGK
M.W. :
Calculated molecular mass (kDa): 83.8; Estimated by SDS-PAGE under reducing condition (kDa): 3 major bands 100-110, 80-90 & 60-70 Kda probably due to proteolytic cleavages within the ECD of CD93
Calculated PI :
5.44
Calculated Extinction Coefficients :
(M-1 cm-1, at 280nm): 95820
Endotoxin Level :
>90% judged by SDS-PAGE under reducing condition (see the gel image above)
Formulation :
Supplied at 0.5 mg/ml in sterile PBSpH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule) using the standard procedure.
Endotoxin Level :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Biological Activity :
Molecule Class :
1-Pass Type I Transmembrane
Gene Synonym :
<0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Gene Family :
CD93; C1qR1; C1qRP; CDw93; ECSM3; MXRA4; C1qR(P); dJ737E23.1
Research Area :
Immunology
Pathway/Disease :
Complement Receptor
Species :
Human
CD Antigen :
CD93
References :
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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